Webster's English Dictionary

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pox

1. pox \'pa:ks\ n or pox or pox.es [alter. of pocks, pl. of pock] pl  1a: a 
   virus disease characterized by pustules or eruptions {chicken po x} archaic 
    1b: SMALLPOX  1c: SYPHILIS  2: an afflictive rash : PLAGUE {a ~ on him} 
2. pox vt archaic  : to infect with a pox and exp. with syphilis