Webster's English Dictionary

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vicissitude

Cross references:
  1. change                 2. difficulty            
 
vi.cis.si.tude \v*-'sis-*-.t(y)u:d, vi--\ n [MF, fr. L vicissitudo, fr. 
   vicissim in turn, fr. vicis chang]e, alternation - more at WEEK 1a: the 
   quality or state of being changeable : MUTABILITY  1b: natural change or 
   mutation visible in nature or in human affiars  2a: an accident of fortune 
   (as of prosperity or happiness)  2b: alternating change : SUCCESSION